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Article

Numb antagonizes Notch signaling to specify sibling neuron cell fates.

Neuron - 1 Jul 1996

Spana E P, Doe C Q

Abstract excerpt

Asymmetric cell divisions play a key role in establishing neuronal diversity in the mammalian and Drosophila CNS, but the mechanisms involved are mostly unknown. The Drosophila MP2 precursor divides asymmetrically to generate the dMP2/vMP2 interneurons. Delta-Notch signaling is required to specify vMP2 fate, whereas the localized determinant Numb is segregated into dMP2 and is required to specify dMP2 fate....

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Identifiers

PMID: 8755475
DOI: 10.1016/s0896-6273(00)80277-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Numb antagonizes Notch signaling to specify sibling neuron cell fates.PMID 8755475Read ↗

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Jumeaux, a novel Drosophila winged-helix family protein, is required for generating asymmetric sibling neuronal cell fates.Semantic proximity Read ↗

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Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis.Semantic proximity Read ↗

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