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Article

MDM2 can interact with the C-terminus of AID but it is inessential for antibody diversification in DT40 B cells.

Molecular immunology - 1 Mar 2006

MacDuff Donna A, Neuberger Michael S, Harris Reuben S

Abstract excerpt

Activation-induced deaminase (AID) is essential for immunoglobulin gene diversification by the distinct processes of class switch recombination, somatic hypermutation and gene conversion. Most evidence indicates that AID triggers these reactions through the direct deamination of cytosine residues in the DNA. However, AID is predominantly cytoplasmic and the mechanism that directs it to the immunoglobulin loci...

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Share to AICDA (Activation-Induced Cytidine Deaminase)
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16122802
DOI: 10.1016/j.molimm.2005.07.024

Genes

MDM2
APOB
APOBEC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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