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Article

Genomic Alterations in CIITA Are Frequent in Primary Mediastinal Large B Cell Lymphoma and Are Associated with Diminished MHC Class II Expression.

Cell reports - 17 Nov 2015

Mottok Anja, Woolcock Bruce, Chan Fong Chun, Tong King Mong, Chong Lauren, Farinha Pedro, Telenius Adèle, Chavez Elizabeth, Ramchandani Suvan, Drake Marie, Boyle Merrill, Ben-Neriah Susana, Scott David W, Rimsza Lisa M, Siebert Reiner, Gascoyne Randy D, Steidl Christian

Abstract excerpt

Primary mediastinal large B cell lymphoma (PMBCL) is an aggressive non-Hodgkin's lymphoma, predominantly affecting young patients. We analyzed 45 primary PMBCL tumor biopsies and 3 PMBCL-derived cell lines for the presence of genetic alterations involving the major histocompatibility complex (MHC) class II transactivator CIITA and found frequent aberrations consisting of structural genomic rearrangements,...

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Share to Histocompatibility Antigens Class II
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Lymphoma, Large B-Cell, Diffuse

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Source

Identifiers

PMID: 26549456
DOI: 10.1016/j.celrep.2015.10.008

Genes

CIITA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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