Genomic Alterations in CIITA Are Frequent in Primary Mediastinal Large B Cell Lymphoma and Are Associated with Diminished MHC Class II Expression.

doi:10.1016/j.celrep.2015.10.008

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Genomic Alterations in CIITA Are Frequent in Primary Mediastinal Large B Cell Lymphoma and Are Associated with Diminished MHC Class II Expression.

Cell reports - 17 Nov 2015

Mottok Anja, Woolcock Bruce, Chan Fong Chun, Tong King Mong, Chong Lauren, Farinha Pedro, Telenius Adèle, Chavez Elizabeth, Ramchandani Suvan, Drake Marie, Boyle Merrill, Ben-Neriah Susana, Scott David W, Rimsza Lisa M, Siebert Reiner, Gascoyne Randy D, Steidl Christian

Abstract excerpt

Primary mediastinal large B cell lymphoma (PMBCL) is an aggressive non-Hodgkin's lymphoma, predominantly affecting young patients. We analyzed 45 primary PMBCL tumor biopsies and 3 PMBCL-derived cell lines for the presence of genetic alterations involving the major histocompatibility complex (MHC) class II transactivator CIITA and found frequent aberrations consisting of structural genomic rearrangements,...

Topics

Cell Line
DNA Mutational Analysis
Gene Expression
Genetic Association Studies
Genetic Predisposition to Disease
Histocompatibility Antigens Class II
Humans
Introns
Lymphoma, Large B-Cell, Diffuse

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mediastinal Neoplasms

Nuclear Proteins

Point Mutation

Sequence Deletion

Trans-Activators

Tumor Escape

Source

Open in PubMed

Identifiers

PMID: 26549456
DOI: 10.1016/j.celrep.2015.10.008

Genes

CIITA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic Alterations in CIITA Are Frequent in Primary Mediastinal Large B Cell Lymphoma and Are Associated with Diminished MHC Class II Expression.PMID 26549456Read ↗

Structural genomic alterations in primary mediastinal large B-cell lymphoma.Semantic proximity Read ↗

Integrative genomic analysis identifies key pathogenic mechanisms in primary mediastinal large B-cell lymphomaSemantic proximity Read ↗

Loss of major histocompatibility class II expression in non-immune-privileged site diffuse large B-cell lymphoma is highly coordinated and not due to chromosomal deletionsSemantic proximity Read ↗

Genomic alterations underlying immune privilege in malignant lymphomasSemantic proximity Read ↗

Genomic analyses of PMBL reveal new drivers and mechanisms of sensitivity to PD-1 blockade.Semantic proximity Read ↗

The molecular pathogenesis of primary mediastinal large B-cell lymphomaSemantic proximity Read ↗

IRF8-mutant B cell lymphoma evades immunity through a CD74-dependent deregulation of antigen processing and presentation in MHC CII complexesSemantic proximity Read ↗

An epigenetic pathway regulates MHC-II expression and function in B cell lymphoma modelsSemantic proximity Read ↗

Genomic rearrangements involving programmed death ligands are recurrent in primary mediastinal large B-cell lymphoma.Semantic proximity Read ↗

Activating mutations affecting the NF-kappa B pathway and EZH2-mediated epigenetic regulation are rare events in primary mediastinal large B-cell lymphoma.Semantic proximity Read ↗

Inactivation of CREBBP expands the germinal center B cell compartment, down-regulates MHCII expression and promotes DLBCL growth.Semantic proximity Read ↗

Genetic Characterization of Primary Mediastinal B-Cell Lymphoma: Pathogenesis and Patient OutcomesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.