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Article

DIS3 mutations enhance AID-driven translocations during B-cell activation, promoting transformation to multiple myeloma.

Nature communications - 14 Mar 2026

Kuliński Tomasz M, Gewartowska Olga, Mahé Mélanie, Kasztelan Karolina, Durys Nina, Stroynowska-Czerwińska Anna, Jedynak-Slyvka Marta, Owczarek Ewelina P, Chaudhury Debadeep, Nowotny Marcin, Pękowska Aleksandra, Séraphin Bertrand, Dziembowski Andrzej

Abstract excerpt

DIS3, a key nuclear RNA-degrading enzyme, is essential for immunoglobulin class switch recombination (CSR), promoting activation-induced cytidine deaminase (AID) activity on both DNA strands to induce double-strand DNA breaks. During somatic hypermutation, AID-dependent lesions predominantly occur on the non-template DNA strand. Dominant mutations impairing DIS3 exoribonucleolytic activity are common in multiple...

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Topics

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Share to AICDA (Activation-Induced Cytidine Deaminase)
Share to Cytidine Deaminase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Breaks, Double-Stranded

Share to Exosome Multienzyme Ribonuclease Complex

Share to Immunoglobulin Class Switching

Share to Lymphocyte Activation

Share to Multiple Myeloma

Share to Translocation, Genetic

Source

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Identifiers

PMID: 41832173
DOI: 10.1038/s41467-026-70386-3
PMCID: PMC13133341

Genes

DIS3
IGH

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

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DIS3 mutations enhance AID-driven translocations during B-cell activation, promoting transformation to multiple myeloma.PMID 41832173Read ↗

Multiple Myeloma associated DIS3 mutations drive AID-dependent IGH TranslocationsSemantic proximity Read ↗

Somatic DIS3 mutations in Multiple Myeloma arise early in clonal evolution, but are later counterselected due to toxicitySemantic proximity Read ↗

The 3' to 5' Exoribonuclease DIS3: From Structure and Mechanisms to Biological Functions and Role in Human DiseaseSemantic proximity Read ↗

Noncoding RNA processing by DIS3 regulates chromosomal architecture and somatic hypermutation in B cells.Semantic proximity Read ↗

Loss of ribonuclease DIS3 hampers genome integrity in myeloma by disrupting DNA:RNA hybrid metabolismSemantic proximity Read ↗

DIS3: The Enigmatic Gene in Multiple Myeloma.Semantic proximity Read ↗

The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes.Semantic proximity Read ↗

The molecular spectrum and clinical impact of DIS3 mutations in multiple myeloma.Semantic proximity Read ↗

A Hyper-IgM Syndrome Mutation in Activation-Induced Cytidine Deaminase Disrupts G-Quadruplex Binding and Genome-wide Chromatin Localization.Semantic proximity Read ↗

Mutations, kataegis and translocations in B cells: understanding AID promiscuous activity.Semantic proximity Read ↗

Restricting activation‐induced cytidine deaminase tumorigenic activity in B lymphocytesSemantic proximity Read ↗

AID in Antibody Diversification: There and Back Again.Semantic proximity Read ↗

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