Article
AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations.
Molecular cell - 25 Nov 2009
Robbiani Davide F, Bunting Samuel, Feldhahn Niklas, Bothmer Anne, Camps Jordi, Deroubaix Stephanie, McBride Kevin M, Klein Isaac A, Stone Gary, Eisenreich Thomas R, Ried Thomas, Nussenzweig André, Nussenzweig Michel C
Abstract excerpt
Cancer-initiating translocations such as those associated with lymphomas require the formation of paired DNA double-strand breaks (DSBs). Activation-induced cytidine deaminase (AID) produces widespread somatic mutation in mature B cells; however, the extent of "off-target" DSB formation and its role in translocation-associated malignancy is unknown. Here, we show that deregulated expression of AID causes...
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