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Oncogenic events triggered by AID, the adverse effect of antibody diversification

4 Sept 2007

Abstract excerpt

The generation of an efficient immune response depends on highly refined mechanisms of antibody diversification. Two of these mechanisms, somatic hypermutation (SHM) and class switch recombination (CSR), are initiated by activation-induced cytidine deaminase (AID) upon antigen stimulation of mature B cells. AID deaminates cytosines on the DNA of Ig genes thereby generating a lesion that can be processed into a...

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PMID: 17804422
DOI: 10.1093/carcin/bgm201

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