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Article

A combined nuclear and nucleolar localization motif in activation-induced cytidine deaminase (AID) controls immunoglobulin class switching.

Journal of molecular biology - 23 Jan 2013

Hu Yi, Ericsson Ida, Torseth Kathrin, Methot Stephen P, Sundheim Ottar, Liabakk Nina B, Slupphaug Geir, Di Noia Javier M, Krokan Hans E, Kavli Bodil

Abstract excerpt

Activation-induced cytidine deaminase (AID) is a DNA mutator enzyme essential for adaptive immunity. AID initiates somatic hypermutation and class switch recombination (CSR) by deaminating cytosine to uracil in specific immunoglobulin (Ig) gene regions. However, other loci, including cancer-related genes, are also targeted. Thus, tight regulation of AID is crucial to balance immunity versus disease such as...

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Source

Identifiers

PMID: 23183374
DOI: 10.1016/j.jmb.2012.11.026

Genes

CTNNBL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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A combined nuclear and nucleolar localization motif in activation-induced cytidine deaminase (AID) controls immunoglobulin class switching.PMID 23183374Read ↗

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Structural phylogenetic analysis of activation-induced deaminase function.Semantic proximity Read ↗

Activation-induced Cytidine Deaminase in B Cell Immunity and CancersSemantic proximity Read ↗

A licensing step links AID to transcription elongation for mutagenesis in B cells.Semantic proximity Read ↗

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Mutations, kataegis and translocations in B cells: understanding AID promiscuous activity.Semantic proximity Read ↗

Epigenetic targeting of activation-induced cytidine deaminaseSemantic proximity Read ↗

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