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Article

The mechanisms regulating the subcellular localization of AID.

Nucleus (Austin, Tex.) - 1 Jan 2000

Patenaude Anne-Marie, Di Noia Javier M

Abstract excerpt

Activation induced deaminase (AID) is a unique enzyme that directly introduces mutations in the immunoglobulin genes to generate antibody diversity during the humoral immune response. Since this mutator enzyme poses a measurable risk of off-target mutation, which can be deleterious or transforming for a cell, several regulatory mechanisms exist to control its activity. At least three of these mechanisms affect...

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Identifiers

PMID: 21327080
DOI: 10.4161/nucl.1.4.12107
PMCID: PMC3027040

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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