Article
CD72 polymorphisms associated with alternative splicing modify susceptibility to human systemic lupus erythematosus through epistatic interaction with FCGR2B.
Human molecular genetics - 1 Dec 2004
Hitomi Yuki, Tsuchiya Naoyuki, Kawasaki Aya, Ohashi Jun, Suzuki Takeshi, Kyogoku Chieko, Fukazawa Toru, Bejrachandra Sasitorn, Siriboonrit Usanee, Chandanayingyong Dasnayanee, Suthipinittharm Puan, Tsao Betty P, Hashimoto Hiroshi, Honda Zen-ichiro, Tokunaga Katsushi
Abstract excerpt
We previously reported association of FCGR2B-Ile232Thr with systemic lupus erythematosus (SLE) in three Asian populations. Because polymorphism of CD72, another inhibitory receptor of B cells, was associated with murine SLE, we identified human CD72 polymorphisms, tested their association with SLE and examined genetic interaction with FCGR2B in the Japanese (160 SLE, 277 controls), Thais (87 SLE, 187 controls)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.