Article
Fcgamma receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus: contribution of FCGR2B to genetic susceptibility.
Arthritis and rheumatism - 1 May 2002
Kyogoku Chieko, Dijstelbloem Hilde M, Tsuchiya Naoyuki, Hatta Yoko, Kato Hitoshi, Yamaguchi Akihiro, Fukazawa Toru, Jansen Marc D, Hashimoto Hiroshi, van de Winkel Jan G J, Kallenberg Cees G M, Tokunaga Katsushi
Abstract excerpt
OBJECTIVE: Human low-affinity Fcgamma receptors (FcgammaR) constitute a clustered gene family located on chromosome 1q23, that consists of FcgammaRIIA, IIB, IIC, IIIA, and IIIB genes. FcgammaRIIB is unique in its ability to transmit inhibitory signals, and recent animal studies demonstrated a role for FcgammaRIIB deficiency in the development of autoimmunity. Genetic variants of FcgammaRIIA, IIIA, and IIIB and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.