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Article

FCRL3, an autoimmune susceptibility gene, has inhibitory potential on B-cell receptor-mediated signaling.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2009

Kochi Yuta, Myouzen Keiko, Yamada Ryo, Suzuki Akari, Kurosaki Tomohiro, Nakamura Yusuke, Yamamoto Kazuhiko

Abstract excerpt

A polymorphism that up-regulates the expression of Fc receptor-like 3 (FCRL3) gene has recently been described as predisposing for several human autoimmune diseases. FCRL3 is preferentially expressed on B cells and is unique in displaying both an ITAM and an ITIM in the cytosolic domain, suggesting signaling functions. Herein, we show that FCRL3 potentially inhibits BCR-mediated signaling, using murine...

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Source

Identifiers

PMID: 19843936
DOI: 10.4049/jimmunol.0901982

Genes

FCRL3
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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