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Article

Diversity of human immune system multigene families and its implication in the genetic background of rheumatic diseases.

Current medicinal chemistry - 1 Jan 2007

Tsuchiya Naoyuki, Kyogoku Chieko, Miyashita Risa, Kuroki Kimiko

Abstract excerpt

A large number of molecules in the immune system are encoded by multigene families. These genes are rich in pairs of activating and inhibitory receptors that share the same ligands, thereby playing a crucial role in immunoregulation. Furthermore, multigene families tend to be highly polymorphic. Thus, multigene families are strong candidates for containing genes that enhance susceptibility to immune...

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Identifiers

PMID: 17305544
DOI: 10.2174/092986707779941041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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