Article
Association of a transmembrane polymorphism of Fcgamma receptor IIb (FCGR2B) with systemic lupus erythematosus in Taiwanese patients.
Arthritis and rheumatism - 1 Dec 2006
Chen Ji-Yih, Wang Chin Man, Ma Chung-Chun, Luo Shue-Fen, Edberg Jeffrey C, Kimberly Robert P, Wu Jianming
Abstract excerpt
OBJECTIVE: To investigate the possible association of the Fcgamma receptor IIb (FcgammaRIIb) Ile/Thr187 transmembrane domain polymorphism, which significantly affects receptor signaling, with susceptibility to systemic lupus erythematosus (SLE) in Taiwanese patients. METHODS: We used matrix-assisted laser desorption ionization-time-of-flight mass spectrometry to genotype 351 Taiwanese SLE patients and 372 age-...
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