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Article

Loss of suppressor-of-fused function promotes tumorigenesis.

Oncogene - 27 Sept 2007

Lee Y, Kawagoe R, Sasai K, Li Y, Russell H R, Curran T, McKinnon P J

Abstract excerpt

The Sonic Hedgehog (SHH) signaling pathway is indispensable for development, and functions to activate a transcriptional program modulated by the GLI transcription factors. Here, we report that loss of a regulator of the SHH pathway, Suppressor of Fused (Sufu), resulted in early embryonic lethality in the mouse similar to inactivation of another SHH regulator, Patched1 (Ptch1). In contrast to Ptch1+/- mice,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17452975
DOI: 10.1038/sj.onc.1210467

Genes

SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Loss of suppressor-of-fused function promotes tumorigenesis.PMID 17452975Read ↗

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No evidence for mutations or altered expression of the Suppressor of Fused gene (SUFU) in primitive neuroectodermal tumours.Semantic proximity Read ↗

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