Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis.

Nature - 7 May 2009

Wilson Christopher W, Nguyen Catherine T, Chen Miao-Hsueh, Yang Jehn-Hsiahn, Gacayan Rhodora, Huang Jie, Chen Jau-Nian, Chuang Pao-Tien

Abstract excerpt

Hedgehog (Hh) signalling is essential for several aspects of embryogenesis. In Drosophila, Hh transduction is mediated by a cytoplasmic signalling complex that includes the putative serine-threonine kinase Fused (Fu) and the kinesin Costal 2 (Cos2, also known as Cos), yet Fu does not have a conserved role in Hh signalling in mammals. Mouse Fu (also known as Stk36) mutants are viable and seem to respond normally...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Axin Protein
Share to Cilia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hedgehog Proteins

Share to Kinesins

Share to Microtubule-Associated Proteins

Share to Repressor Proteins

Share to Signal Transduction

Share to Zebrafish

Source

Open in PubMed Open full text

Identifiers

PMID: 19305393
DOI: 10.1038/nature07883
PMCID: PMC3204898

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis.PMID 19305393Read ↗

The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development.Semantic proximity Read ↗

Fused (Stk36) is a ciliary protein required for central pair assembly and motile cilia orientation in the mammalian oviductSemantic proximity Read ↗

Mice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic development.Semantic proximity Read ↗

A complex of distal appendage-associated kinases linked to human disease regulates ciliary trafficking and stabilitySemantic proximity Read ↗

Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling.Semantic proximity Read ↗

An intramolecular association between two domains of the protein kinase Fused is necessary for Hedgehog signaling.Semantic proximity Read ↗

The medaka dhc2 mutant reveals conserved and distinct mechanisms of Hedgehog signaling in teleosts.Semantic proximity Read ↗

A cytoskeletal scaffold promotes motile cilia assembly by regulating transition-zone integritySemantic proximity Read ↗

Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus.Semantic proximity Read ↗

The primary cilium as a Hedgehog signal transduction machine.Semantic proximity Read ↗

Genetic dissection of the Drosophila Cubitus interruptus signaling complex.Semantic proximity Read ↗

Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.