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Article

The putative protein kinase Stk36 is essential for ciliogenesis and CSF flow by associating with Ulk4

16 Aug 2023

Abstract excerpt

Abstract Motile cilia lining on the ependymal cells are crucial for cerebrospinal fluid (CSF) flow and its dysfunction is often associated with hydrocephalus. Unc51‐like‐kinase 4 (Ulk4) was previously linked to CSF flow and motile ciliogenesis in mice, as the hypomorph mutant of Ulk4 ( Ulk4 tm1a/tm1a ) developed hydrocephalic phenotype resulted from defective ciliogenesis and disturbed ciliary motility, while the...

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PMID: 37584603
DOI: 10.1096/fj.202300481r

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