Article
Nitrogen-substitution effect on in vivo mutagenicity of chrysene.
Mutation research - 5 Sept 2005
Yamada Katsuya, Suzuki Takayoshi, Kohara Arihiro, Kato Taka-Aki, Hayashi Makoto, Mizutani Takaharu, Saeki Ken-Ichi
Abstract excerpt
We have previously reported the in vivo mutagenicity of aza-polycyclic aromatic hydrocarbons (azaPAHs), such as quinoline, benzo[f]quinoline, benzo[h]quinoline, 1,7-phenanthroline and 10-azabenzo[a]pyrene. The 1,10-diazachrysene (1,10-DAC) and 4,10-DAC, nitrogen-substituted analogs of chrysene, were shown to exhibit mutagenicity in Salmonella typhimurium TA100 in the presence of rat liver S9 and human liver...
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