Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

LacI transgenic animal study: relationships among DNA-adduct levels, mutant frequencies and cancer incidences.

Mutation research - 2 Jun 2001

Nagao M, Ochiai M, Okochi E, Ushijima T, Sugimura T

Abstract excerpt

In the processes of carcinogenesis caused by genotoxic carcinogens, DNA-adduct formation and resultant genetic changes are crucially important. In this report, the relationship between DNA-adduct levels and mutant frequencies (MFs), DNA-adduct levels and cancer incidences, and MFs and cancer incidences induced by heterocyclic amines (HCAs), to which humans are exposed on daily basis were investigated. There was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amines
Share to Animals, Genetically Modified
Share to Carcinogens

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Adducts

Share to Escherichia coli Proteins

Share to Heterocyclic Compounds

Share to Lac Repressors

Share to Quinolines

Source

Identifiers

PMID: 11376693
DOI: 10.1016/s0027-5107(01)00113-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

LacI transgenic animal study: relationships among DNA-adduct levels, mutant frequencies and cancer incidences.PMID 11376693Read ↗

DNA adduct level induced by 2-amino-3,4-dimethylimidazo[4,5-f]-quinoline in Big Blue mice does not correlate with mutagenicity.Semantic proximity Read ↗

In vivo genotoxicity of 2-amino-3,8-dimethylimidazo[4, 5-f]quinoxaline in lacI transgenic (Big Blue) mice.Semantic proximity Read ↗

Transgenic models for detection of mutations in tumors and normal tissues of rodents.Semantic proximity Read ↗

Frequency and spectrum of lacI mutations in the liver of Big Blue mice following the administration of genotoxic carcinogens singly and in series.Semantic proximity Read ↗

Agreement of mutational characteristics of heterocyclic amines in lacI of the Big Blue mouse with those in tumor related genes in rodents.Semantic proximity Read ↗

Target organ and time-course in the mutagenicity of five carcinogens in MutaMouse: a summary report of the second collaborative study of the transgenic mouse mutation assay by JEMS/MMS.Semantic proximity Read ↗

Organ variation in the mutagenicity of MeIQ in Big Blue lacI transgenic mice.Semantic proximity Read ↗

Mutational spectrum of dimethylnitrosamine in the liver of 3- and 6-week-old lacI transgenic mice.Semantic proximity Read ↗

Comparison of hprt and lacI mutant frequency with DNA adduct formation in N-hydroxy-2-acetylaminofluorene-treated Big Blue rats.Semantic proximity Read ↗

Low dose genotoxicity of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in gpt delta transgenic mice.Semantic proximity Read ↗

Spectrum of mutations in kidney, stomach, and liver from lacI transgenic mice recovered after treatment with tris(2,3-dibromopropyl)phosphate.Semantic proximity Read ↗

Genotoxicity of 3-methylcholanthrene in liver of transgenic big Blue mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.