Article
Assessment of 1,3-butadiene mutagenicity in the bone marrow of B6C3F1 lacI transgenic mice (Big Blue): a review of mutational spectrum and lacI mutant frequency after a 5-day 625 ppm 1,3-butadiene exposure.
Environmental and molecular mutagenesis - 1 Jan 1996
Recio L, Meyer K G, Pluta L J, Moss O R, Saranko C J
Abstract excerpt
1,3-Butadiene (BD) is a carcinogen that is bioactivated to at least two genotoxic metabolites. In the present article, we review briefly our previous studies on the in vivo mutagenicity and mutational spectra of BD in bone marrow and extend these studies to examine the effect of exposure time (5-...
Topics
- Administration, Inhalation
- Animals
- Bacterial Proteins
- Bone Marrow
- Butadienes
- Escherichia coli Proteins
- Lac Repressors
- Male
- Mice
- Mice, Transgenic
- Mutagenicity Tests
- Mutagens
- Mutation
- Repressor Proteins
- Time Factors