Article
Effect of 10-aza-substitution on benzo[a]pyrene mutagenicity in vivo and in vitro.
Mutation research - 26 Nov 2002
Yamada Katsuya, Suzuki Takayoshi, Kohara Arihiro, Hayashi Makoto, Hakura Atsushi, Mizutani Takaharu, Saeki Ken-ichi
Abstract excerpt
Benzo[a]pyrene (BaP), an environmental carcinogen, shows genotoxicity after metabolic transformation into the bay-region diol epoxide, BaP-7,8-diol 9,10-epoxide. 10-Azabenzo[a]pyrene (10-azaBaP), in which a ring nitrogen is located in the bay-region, is also a carcinogen and shows mutagenicity in the Ames test in the presence of the rat liver microsomal enzymes. In order to evaluate the effect of aza-substitution...
Topics
- Animals
- Base Sequence
- Benzo(a)pyrene
- Benzopyrenes
- Cytochrome P-450 CYP1A1
- Humans
- Male
- Mice
- Mice, Transgenic
- Microsomes, Liver
- Molecular Sequence Data