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Article

Effect of 10-aza-substitution on benzo[a]pyrene mutagenicity in vivo and in vitro.

Mutation research - 26 Nov 2002

Yamada Katsuya, Suzuki Takayoshi, Kohara Arihiro, Hayashi Makoto, Hakura Atsushi, Mizutani Takaharu, Saeki Ken-ichi

Abstract excerpt

Benzo[a]pyrene (BaP), an environmental carcinogen, shows genotoxicity after metabolic transformation into the bay-region diol epoxide, BaP-7,8-diol 9,10-epoxide. 10-Azabenzo[a]pyrene (10-azaBaP), in which a ring nitrogen is located in the bay-region, is also a carcinogen and shows mutagenicity in the Ames test in the presence of the rat liver microsomal enzymes. In order to evaluate the effect of aza-substitution...

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PMID: 12438015
DOI: 10.1016/s1383-5718(02)00240-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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