Article
In vivo mutagenicity of benzo[f]quinoline, benzo[h]quinoline, and 1,7-phenanthroline using the lacZ transgenic mice.
Mutation research - 11 Apr 2004
Yamada Katsuya, Suzuki Takayoshi, Kohara Arihiro, Hayashi Makoto, Mizutani Takaharu, Saeki Ken-Ichi
Abstract excerpt
Phenanthrene, a simplest angular polycyclic aromatic hydrocarbon with a bay-region in its molecule, is reported to be non-mutagenic, although most angular (non-linear) polycyclic aromatic hydrocarbons, such as benzo[a]pyrene and chrysene, are known to show genotoxicity after metabolic transformation into a bay-region diol epoxide. On the other hand, benzo[f]quinoline (BfQ), benzo[h]quinoline (BhQ), and...
Topics
- Animals
- Base Sequence
- DNA Primers
- Lac Operon
- Liver
- Lung
- Mice
- Mice, Transgenic
- Models, Chemical
- Molecular Sequence Data
- Mutagenesis
- Mutagenicity Tests
- Mutation
- Phenanthrolines
- Quinolines