Article
Nitrogen-substitution effects on the mutagenicity and cytochrome P450 isoform-selectivity of chrysene analogs.
Mutation research - 5 Sept 2005
Yamada Katsuya, Hakura Atsushi, Kato Taka-Aki, Mizutani Takaharu, Saeki Ken-Ichi
Abstract excerpt
Nitrogen-containing analogs of chrysene, 1,10-diazachrysene (1,10-DAC) and 4,10-DAC, were tested for mutagenicity in Salmonella typhimurium TA100 in the presence of rat liver S9 and human liver microsomes to investigate the effect of nitrogen-substitution. Although these DACs could not be converted to the bay-region diol epoxide because of their nitrogen atoms in the bay-region epoxide or diol moiety, DACs were...
Topics
- Animals
- Chrysenes
- Cytochrome P-450 CYP1A2
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Humans
- Isoenzymes
- Liver
- Microsomes, Liver
- Molecular Structure
- Mutagenicity Tests