Potent genotoxicity of aminophenylnorharman, formed from non-mutagenic norharman and aniline, in the liver of gpt delta transgenic mouse.

doi:10.1093/carcin/bgg170

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Article

Potent genotoxicity of aminophenylnorharman, formed from non-mutagenic norharman and aniline, in the liver of gpt delta transgenic mouse.

Carcinogenesis - 1 Dec 2003

Masumura Ken-ichi, Totsuka Yukari, Wakabayashi Keiji, Nohmi Takehiko

Abstract excerpt

Aminophenylnorharman (APNH) is formed from non-mutagenic norharman and aniline, and is mutagenic to Salmonella typhimurium TA98 with S9 mix. Norharman and aniline are present in cigarette smoke and cooked foods and both compounds are detected in human urine samples, suggesting that APNH could be a mutagenic and carcinogenic human risk factor. The purpose of the present study was to determine the in vivo...

Topics

Aniline Compounds
Animals
Carbolines
Carcinogens
Colon
Colonic Neoplasms
CpG Islands
DNA Mutational Analysis
Dose-Response Relationship, Drug
Gene Deletion
Harmine
Humans
Indoles
Liver
Liver Neoplasms

Source

Open in PubMed

Identifiers

PMID: 12970073
DOI: 10.1093/carcin/bgg170

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Male

Mice

Mice, Inbred C57BL