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Dinitropyrenes induce gene mutations in multiple organs of the lambda/lacZ transgenic mouse (Muta Mouse).

Mutation research - 25 Mar 2002

Kohara Arihiro, Suzuki Takayoshi, Honma Masamitsu, Oomori Takashi, Ohwada Tomohiko, Hayashi Makoto

Abstract excerpt

Dinitropyrenes (DNPs), 1,3-, 1,6- and 1,8-dinitropyrene, are carcinogenic compounds found in diesel engine exhaust. DNPs are strongly mutagenic in the bacterial mutation assay (Ames test), mainly inducing frameshift type mutations. To assess mutagenicity of DNPs in vivo is important in evaluating their possible involvement in diesel exhaust-induced carcinogenesis in human. For this purpose, we used the...

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PMID: 11909756
DOI: 10.1016/s1383-5718(02)00007-4

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