Relationships of DNA adduct formation, K-ras activating mutations and tumorigenic activities of 6-nitrochrysene and its metabolites in the lungs of CD-1 mice.

doi:10.1093/carcin/15.7.1377

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Article

Relationships of DNA adduct formation, K-ras activating mutations and tumorigenic activities of 6-nitrochrysene and its metabolites in the lungs of CD-1 mice.

Carcinogenesis - 1 Jul 1994

Li E E, Heflich R H, Bucci T J, Manjanatha M G, Blaydes B S, Delclos K B

Abstract excerpt

6-Nitrochrysene (6-NC), an environmental pollutant and a potent mouse lung carcinogen, is activated by two major metabolic pathways to yield DNA adducts derived from either trans-1,2-dihydro-1,2-dihydroxy-6-aminochrysene (1,2-DHD-6-AC) or N-hydroxy-6-aminochrysene (N-OH-6-AC). While the former pa...

Topics

Adenocarcinoma
Adenoma
Animals
Base Sequence
Chrysenes
DNA
Genes, ras
Lung Neoplasms
Male
Mice
Molecular Sequence Data
Mutation

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