Article
Relationships of DNA adduct formation, K-ras activating mutations and tumorigenic activities of 6-nitrochrysene and its metabolites in the lungs of CD-1 mice.
Carcinogenesis - 1 Jul 1994
Li E E, Heflich R H, Bucci T J, Manjanatha M G, Blaydes B S, Delclos K B
Abstract excerpt
6-Nitrochrysene (6-NC), an environmental pollutant and a potent mouse lung carcinogen, is activated by two major metabolic pathways to yield DNA adducts derived from either trans-1,2-dihydro-1,2-dihydroxy-6-aminochrysene (1,2-DHD-6-AC) or N-hydroxy-6-aminochrysene (N-OH-6-AC). While the former pathway has been shown to be the major activation pathway leading to DNA adducts in mice treated with 6-NC, the potential...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.