Article
Tumorigenicity of nitropolycyclic aromatic hydrocarbons in the neonatal B6C3F1 mouse bioassay and characterization of ras mutations in liver tumors from treated mice.
Cancer letters - 1 Nov 1999
Von Tungeln L S, Xia Q, Herreno-Saenz D, Bucci T J, Heflich R H, Fu P P
Abstract excerpt
The nitropolycyclic aromatic hydrocarbons (nitro-PAHs) 1-, 2-, and 3-nitrobenzo[a]pyrene, 1- and 3-nitrobenzo[e]pyrene, 2- and 3-nitrofluoranthene, 9-nitrodibenz[a,c]anthracene, and two of the parent PAHs fluoranthene and dibenz[a,c]anthracene were tested for tumorigenicity in the neonatal male B6C3F1 mouse. 6-Nitrochrysene was used as a positive control. Mice were administered three intraperitoneal injections of...
Topics
- Animals
- Animals, Newborn
- Carcinogens
- DNA Adducts
- Female
- Genes, ras
- Liver Neoplasms, Experimental
- Male
- Mice
- Mice, Inbred C3H
- Mice, Inbred C57BL