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Article

One-carbon metabolism related gene polymorphisms interact with alcohol drinking to influence the risk of colorectal cancer in Japan.

Carcinogenesis - 1 Dec 2005

Matsuo Keitaro, Ito Hidemi, Wakai Kenji, Hirose Kaoru, Saito Toshiko, Suzuki Takeshi, Kato Tomoyuki, Hirai Takashi, Kanemitsu Yukihide, Hamajima Hiroshi, Tajima Kazuo

Abstract excerpt

One-carbon metabolism, in which folate plays an essential role, is involved in DNA methylation and synthesis, and is suspected of impacting on colorectal carcinogenesis. Alcohol is well recognized as a risk factor for colorectal cancer (CRC) and interactions with one-carbon metabolism have also been suggested. Therefore, functional polymorphisms in genes encoding members of this pathway, MTHFR C677T and A1298C...

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Source

Identifiers

PMID: 16051637
DOI: 10.1093/carcin/bgi196

Genes

MTHFR
MTR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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