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Article

Association of polymorphisms in one-carbon metabolizing genes with breast cancer risk in Syrian women.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Aug 2012

Lajin Bassam, Alhaj Sakur Amir, Ghabreau Lina, Alachkar Amal

Abstract excerpt

Dietary folate status as well as polymorphisms in one-carbon metabolism genes may affect the risk of breast cancer through aberrant DNA methylation and altered nucleotide synthesis and DNA repair. A large number of studies investigated the role of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) polymorphisms in breast cancer with inconsistent results. Association between...

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Identifiers

PMID: 22373582
DOI: 10.1007/s13277-012-0354-y

Genes

MTHFR
MTRR

Variants

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