Article
Association of polymorphisms in one-carbon metabolism genes and postmenopausal breast cancer incidence.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jun 2007
Stevens Victoria L, McCullough Marjorie L, Pavluck Alexandre L, Talbot Jeffrey T, Feigelson Heather S, Thun Michael J, Calle Eugenia E
Abstract excerpt
The interconversion of folates by the one-carbon metabolism pathway is essential for the synthesis of precursors used in DNA synthesis, repair, and methylation. Perturbations in this pathway can disrupt these processes and are hypothesized to facilitate carcinogenesis. We investigated associations of 25 candidate polymorphisms in nine one-carbon metabolism genes with risk of postmenopausal breast cancer using 502...
Topics
- Breast Neoplasms
- Female
- Genetic Predisposition to Disease
- Humans
- Incidence
- One-Carbon Group Transferases
- Polymorphism, Single Nucleotide
- Postmenopause