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Article

Gene-diet-interactions in folate-mediated one-carbon metabolism modify colon cancer risk.

Molecular nutrition & food research - 1 Apr 2013

Liu Amy Y, Scherer Dominique, Poole Elizabeth, Potter John D, Curtin Karen, Makar Karen, Slattery Martha L, Caan Bette J, Ulrich Cornelia M

Abstract excerpt

SCOPE: The importance of folate-mediated one-carbon metabolism (FOCM) in colorectal carcinogenesis is emphasized by observations that high dietary folate intake is associated with decreased risk of colon cancer (CC) and its precursors. Additionally, polymorphisms in FOCM-related genes have been repeatedly associated with risk, supporting a causal relationship between folate and colorectal carcinogenesis. METHODS...

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Topics

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Share to DNA (Cytosine-5-)-Methyltransferase 1
Share to DNA (Cytosine-5-)-Methyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycine Hydroxymethyltransferase

Share to Methylenetetrahydrofolate Dehydrogenase (NADP)

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Source

Open in PubMed Open full text

Identifiers

PMID: 22961839
DOI: 10.1002/mnfr.201200180
PMCID: PMC3850763

Genes

DNMT1
MTRR
DHFR
MTHFD1
MTHFR
SHMT1
TCN2
TDG

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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