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Article

One-carbon metabolism-related gene polymorphisms and risk of breast cancer.

Carcinogenesis - 1 Feb 2008

Suzuki Takeshi, Matsuo Keitaro, Hirose Kaoru, Hiraki Akio, Kawase Takakazu, Watanabe Miki, Yamashita Toshinari, Iwata Hiroji, Tajima Kazuo

Abstract excerpt

Environmental exposures and/or genetic background in Japanese population, which might contribute to the relatively low breast cancer incidence rates in Japan, have not been clarified in detail. Folate plays an essential role in DNA methylation and synthesis, and thus may be involved in the development of breast cancer. Functional polymorphisms in genes encoding one-carbon metabolism enzymes,...

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Topics

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Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ferredoxin-NADP Reductase

Share to Folic Acid

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Polymorphism, Genetic

Share to Thymidylate Synthase

Source

Identifiers

PMID: 18174236
DOI: 10.1093/carcin/bgm295

Genes

MTHFR
MTRR
MTR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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