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Article

Impact of one-carbon metabolism-related gene polymorphisms on risk of lung cancer in Japan: a case control study.

Carcinogenesis - 1 Aug 2007

Suzuki Takeshi, Matsuo Keitaro, Hiraki Akio, Saito Toshiko, Sato Shigeki, Yatabe Yasushi, Mitsudomi Tetsuya, Hida Toyoaki, Ueda Ryuzo, Tajima Kazuo

Abstract excerpt

There is substantial evidence that the decreased risk of lung cancer with high intake of vegetables and fruits is linked to folate as a specific nutrient. Functional polymorphisms in genes encoding one-carbon metabolism enzymes, methylenetetrahydrofolate reductase (MTHFR C677T and A1,298C), methionine synthase (MTR A2,756G), methionine synthase reductase (MTRR A66G) and thymidylate synthase, influence folate...

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Source

Identifiers

PMID: 17468511
DOI: 10.1093/carcin/bgm104

Genes

MTHFR
MTRR
MTR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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