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Genetic polymorphisms in folate and alcohol metabolism and breast cancer risk: a case-control study in Thai women.

Breast cancer research and treatment - 1 Oct 2010

Sangrajrang Suleeporn, Sato Yasunori, Sakamoto Hiromi, Ohnami Sumiko, Khuhaprema Thiravud, Yoshida Teruhiko

Abstract excerpt

Dietary folate as well as polymorphic variants in one-carbon metabolism genes may modulate risk of breast cancer through aberrant DNA methylation and altered nucleotide synthesis and repair. Alcohol is well recognized as a risk factor for breast cancer, and interactions with one-carbon metabolism has also been suggested. The purpose of this study is to test the hypothesis that genetic polymorphisms in the folate...

Topics

Adult
Alcohol Drinking
Arylamine N-Acetyltransferase
Biotransformation
Breast Neoplasms
Case-Control Studies
Ethanol
Female
Ferredoxin-NADP Reductase
Folic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Humans

Logistic Models

Middle Aged

Odds Ratio

Phenotype

Polymorphism, Single Nucleotide

Receptors, Dopamine D2

Source

Identifiers

PMID: 20180013
DOI: 10.1007/s10549-010-0804-4

Genes

DRD2
DRD3
MTR
MTRR
NAT2
ALDH2
GSTP1
MTHFR
NAT1
TYMS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Genetic polymorphisms in folate and alcohol metabolism and breast cancer risk: a case-control study in Thai women.PMID 20180013Read ↗

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Relationships among folate, alcohol consumption, gene variants in one-carbon metabolism and p16INK4a methylation and expression in healthy breast tissuesSemantic proximity Read ↗

Joint effects of folate intake and one-carbon-metabolizing genetic polymorphisms on breast cancer risk: a case-control study in China.Semantic proximity Read ↗

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