Article
Identical phenotypes of CatSper1 and CatSper2 null sperm.
The Journal of biological chemistry - 16 Sept 2005
Carlson Anne E, Quill Timothy A, Westenbroek Ruth E, Schuh Sonya M, Hille Bertil, Babcock Donner F
Abstract excerpt
Among several candidate Ca(2+) entry channels in sperm, only CatSper1 and CatSper2 are known to have required roles in male fertility. Past work with CatSper1 null sperm indicates that a critical lesion in hyperactivated motility underlies the infertility phenotype and is associated with an absence of depolarization-evoked Ca(2+)entry. Here we show that failure of hyperactivation of CatSper2 null sperm similarly...
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