Article

Unexplained infertility is frequently caused by defective CatSper function preventing sperm from penetrating the egg coat

2023-03-27

Abstract excerpt

The infertility of many couples seems to rest on an enigmatic dysfunction of the men’s sperm, rendering early diagnosis and evidence-based treatment by medically assisted reproduction impossible. Using a novel laboratory test, we assessed the function of the flagellar Ca 2+ channel CatSper in sperm of almost 2,300 men undergoing a fertility workup. Thereby, we identified a group of men with mutations in CATSPER ge...

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Literature Corpus work: 444b6578-00ae-5874-b305-078e9da124f5
DOI: 10.1101/2023.03.23.23286813

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