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Article

Specific loss of CatSper function is sufficient to compromise fertilizing capacity of human spermatozoa

8 Oct 2015

Abstract excerpt

STUDY QUESTION: Are significant abnormalities of CatSper function present in IVF patients with normal sperm concentration and motility and if so what is their functional significance for fertilization success? SUMMARY ANSWER: Sperm with a near absence of CatSper current failed to respond to activation of CatSper by progesterone and there was fertilization failure at IVF. WHAT IS KNOWN ALREADY: In human...

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PMID: 26453676
DOI: 10.1093/humrep/dev243

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