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Article

Calcium Signaling Through CatSper Channels in Mammalian Fertilization

1 Jun 2010

Abstract excerpt

The molecular mechanisms underlying Ca(2+) entry into sperm are now much more well defined thanks to direct recordings of mature sperm cells. This article reviews the function of a sperm-specific ion channel, CatSper. CatSpers have a clearly defined function in sperm's hyperactivated motility and are essential for male fertility. We propose that physiological stimuli such as zona pellucida and cyclic nucleotides...

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Identifiers

PMID: 20551230
DOI: 10.1152/physiol.00049.2009

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Calcium Signaling Through CatSper Channels in Mammalian FertilizationPMID 20551230Read ↗

CatSper channel, sperm function and male fertility.Semantic proximity Read ↗

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Unexplained infertility is frequently caused by defective CatSper function preventing sperm from penetrating the egg coatSemantic proximity Read ↗

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