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Article

Insights into sperm cell motility signaling through sNHE and the CatSpers.

Molecular and cellular endocrinology - 16 May 2006

Quill Timothy A, Wang Dan, Garbers David L

Abstract excerpt

Successful natural reproduction normally requires vigorously motile spermatozoa. Using a signal peptide trapping strategy, we identified two new genes, a putative sperm Na+/H+ exchanger (sNHE) and the putative cation channel CatSper2, with unique and essential roles in sperm motility. Disruption of the sNHE or CatSper2 genes in mice caused male infertility due to immotile spermatozoa or failed motility...

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Identifiers

PMID: 16413670
DOI: 10.1016/j.mce.2005.12.031

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The Control of Male Fertility by Spermatozoan Ion ChannelsSemantic proximity Read ↗

CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm.Semantic proximity Read ↗

The Cation/Calcium Channel of Sperm (CatSper): A Common Role Played Despite Inter-Species Variation?Semantic proximity Read ↗

A new sperm-specific Na+/H+ exchanger required for sperm motility and fertility.Semantic proximity Read ↗

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