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Article

Human fertilization in vivo and in vitro requires the CatSper channel to initiate sperm hyperactivation

1 Jan 2024

Abstract excerpt

The infertility of many couples rests on an enigmatic dysfunction of the man's sperm. To gain insight into the underlying pathomechanisms, we assessed the function of the sperm-specific multisubunit CatSper-channel complex in the sperm of almost 2,300 men undergoing a fertility workup, using a simple motility-based test. We identified a group of men with normal semen parameters but defective CatSper function....

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38165034
DOI: 10.1172/jci173564

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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