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Article

A Rik1-associated, cullin-dependent E3 ubiquitin ligase is essential for heterochromatin formation.

Genes & development - 15 Jul 2005

Horn Peter J, Bastie Jean-Noël, Peterson Craig L

Abstract excerpt

Heterochromatin is critical for proper centromere and telomere function, and it plays a key role in the transcriptional silencing of specific genomic loci. In fission yeast, the Rik1 protein functions with the Clr4 histone methyltransferase at an early step in heterochromatin formation. Here, we use mass spectrometry and tandem affinity purification of a Rik1-TAP fusion protein to identify Rik1-associated...

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Share to Chromosomal Proteins, Non-Histone
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone-Lysine N-Methyltransferase

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Source

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Identifiers

PMID: 16024659
DOI: 10.1101/gad.1328005
PMCID: PMC1176008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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