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Article

Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly.

Science (New York, N.Y.) - 6 Apr 2001

Nakayama J, Rice J C, Strahl B D, Allis C D, Grewal S I

Abstract excerpt

The assembly of higher order chromatin structures has been linked to the covalent modifications of histone tails. We provide in vivo evidence that lysine 9 of histone H3 (H3 Lys9) is preferentially methylated by the Clr4 protein at heterochromatin-associated regions in fission yeast. Both the conserved chromo- and SET domains of Clr4 are required for H3 Lys9 methylation in vivo. Localization of Swi6, a homolog of...

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PMID: 11283354
DOI: 10.1126/science.1060118

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SET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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