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Article

CRL4-like Clr4 complex in Schizosaccharomyces pombe depends on an exposed surface of Dos1 for heterochromatin silencing.

Proceedings of the National Academy of Sciences of the United States of America - 4 Feb 2014

Kuscu Canan, Zaratiegui Mikel, Kim Hyun Soo, Wah David A, Martienssen Robert A, Schalch Thomas, Joshua-Tor Leemor

Abstract excerpt

Repressive histone H3 lysine 9 methylation (H3K9me) and its recognition by HP1 proteins are necessary for pericentromeric heterochromatin formation. In Schizosaccharomyces pombe, H3K9me deposition depends on the RNAi pathway. Cryptic loci regulator 4 (Clr4), the only known H3K9 methyltransferase in this organism, is a subunit of the Clr4 methyltransferase complex (CLRC), whose composition is reminiscent of a CRL4...

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PMID: 24449894
DOI: 10.1073/pnas.1313096111
PMCID: PMC3918804

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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CRL4-like Clr4 complex in Schizosaccharomyces pombe depends on an exposed surface of Dos1 for heterochromatin silencing.PMID 24449894Read ↗

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