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Article

Role of the fission yeast SUMO E3 ligase Pli1p in centromere and telomere maintenance.

The EMBO journal - 1 Oct 2004

Xhemalce Blerta, Seeler Jacob-S, Thon Geneviève, Dejean Anne, Arcangioli Benoît

Abstract excerpt

Sumoylation represents a conserved mechanism of post-translational protein modification. We report that Pli1p, the unique fission yeast member of the SP-RING family, is a SUMO E3 ligase in vivo and in vitro. pli1Delta cells display no obvious mitotic growth defects, but are sensitive to the microtubule-destabilizing drug TBZ and exhibit enhanced minichromosome loss. The weakened centromeric function of pli1Delta...

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Share to Centromere
Share to Chromosomes, Fungal
Share to Heterochromatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Schizosaccharomyces

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Source

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Identifiers

PMID: 15359282
DOI: 10.1038/sj.emboj.7600394
PMCID: PMC522793

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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