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Article

Raf1 Is a DCAF for the Rik1 DDB1-like protein and has separable roles in siRNA generation and chromatin modification.

PLoS genetics - 1 Feb 2012

Buscaino Alessia, White Sharon A, Houston Douglas R, Lejeune Erwan, Simmer Femke, de Lima Alves Flavia, Diyora Piyush T, Urano Takeshi, Bayne Elizabeth H, Rappsilber Juri, Allshire Robin C

Abstract excerpt

Non-coding transcription can trigger histone post-translational modifications forming specialized chromatin. In fission yeast, heterochromatin formation requires RNAi and the histone H3K9 methyltransferase complex CLRC, composed of Clr4, Raf1, Raf2, Cul4, and Rik1. CLRC mediates H3K9 methylation...

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Share to Cdc20 Proteins
Share to Chromatin Assembly and Disassembly

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Histone-Lysine N-Methyltransferase

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Share to Proto-Oncogene Proteins c-raf

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Source

Open in PubMed Open full text

Identifiers

PMID: 22319459
DOI: 10.1371/journal.pgen.1002499
PMCID: PMC3271066

Genes

DDB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22319459-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Raf1 Is a DCAF for the Rik1 DDB1-like protein and has separable roles in siRNA generation and chromatin modification.PMID 22319459Read ↗

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