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Article

RNA-dependent RNA polymerase is an essential component of a self-enforcing loop coupling heterochromatin assembly to siRNA production.

Proceedings of the National Academy of Sciences of the United States of America - 4 Jan 2005

Sugiyama Tomoyasu, Cam Hugh, Verdel André, Moazed Danesh, Grewal Shiv I S

Abstract excerpt

In fission yeast, factors involved in the RNA interference (RNAi) pathway including Argonaute, Dicer, and RNA-dependent RNA polymerase are required for heterochromatin assembly at centromeric repeats and the silent mating-type region. Previously, we have shown that RNA-induced initiation of transcriptional gene silencing (RITS) complex containing the Argonaute protein and small interfering RNAs (siRNAs) localizes...

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Identifiers

PMID: 15615848
DOI: 10.1073/pnas.0407641102
PMCID: PMC544066

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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RNA-dependent RNA polymerase is an essential component of a self-enforcing loop coupling heterochromatin assembly to siRNA production.PMID 15615848Read ↗

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