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Article

Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.

The Journal of biological chemistry - 22 Jun 2007

Gendron Christi, Kashiwagi Masahide, Lim Ngee Han, Enghild Jan J, Thøgersen Ida B, Hughes Clare, Caterson Bruce, Nagase Hideaki

Abstract excerpt

Aggrecanases have been characterized as proteinases that cleave the Glu373-Ala374 bond of the aggrecan core protein, and they are multidomain metalloproteinases belonging to the ADAMTS (adamalysin with thrombospondin type 1 motifs) family. The first aggrecanases discovered were ADAMTS-4 (aggrecanase 1) and ADAMTS-5 (aggrecanase 2). They contain a zinc catalytic domain followed by non-catalytic ancillary domains,...

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PMID: 17430884
DOI: 10.1074/jbc.M701523200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.PMID 17430884Read ↗

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