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Article

Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing.

The Journal of biological chemistry - 12 Mar 2004

Kashiwagi Masahide, Enghild Jan J, Gendron Christi, Hughes Clare, Caterson Bruce, Itoh Yoshifumi, Nagase Hideaki

Abstract excerpt

ADAMTS-4 (a disintegrin and metalloprotease with thrombospondin motifs) is a multidomain metalloproteinase belonging to the reprolysin family. The enzyme cleaves aggrecan core protein at several sites. Here we report that the non-catalytic ancillary domains of the enzyme play a major role in regulating aggrecanase activity, with the C-terminal spacer domain masking the general proteolytic activity. Expressing a...

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PMID: 14662755
DOI: 10.1074/jbc.M312123200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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