Article

Recombinant manufacturing of multispecies biolubricants

2024-05-05

Abstract excerpt

<h4>ABSTRACT</h4> Lubricin, a lubricating glycoprotein abundant in synovial fluid, forms a low-friction brush polymer interface in tissues exposed to sliding motion including joints, tendon sheaths, and the surface of the eye. Despite its therapeutic potential in diseases such as osteoarthritis and dry eye disease, there are few sources available. Through rational design, we developed a series of recombinant lubr...

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Literature Corpus work: 8b972096-28f8-52b7-9777-c33ef6a42666
DOI: 10.1101/2024.05.05.592580

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