Article

Cathepsin g degrades synovial fluid lubricin: relevance for osteoarthritis pathogenesis

2019-10-15

Abstract excerpt

Lubricin (PRG4) is a mucin type protein that plays an important role in maintaining normal joint function by providing lubrication and chondroprotection. Improper lubricin modification and degradation has been observed in idiopathic osteoarthritis (OA), while the detailed mechanism still remains unknown. We hypothesized that the protease cathepsin G (CG) may participate in degrading lubricin in synovial fluid (SF)...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: eaddd647-aa4d-502c-9bbc-82795efecfc2
DOI: 10.1101/792184

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cathepsin g degrades synovial fluid lubricin: relevance for osteoarthritis pathogenesisDOI 10.1101/792184Read

Investigating lubricin and known cartilage-based biomarkers of osteoarthritis.Semantic proximity Read

Consequences of disease-causing mutations on lubricin protein synthesis, secretion, and post-translational processing.Semantic proximity Read

The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth.Semantic proximity Read

Prg4 and Osteoarthritis: Functions, Regulatory Factors, and Treatment StrategiesSemantic proximity Read

Galectin-3 Binds to Lubricin and Reinforces the Lubricating Boundary Layer of Articular Cartilage.Semantic proximity Read

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis.Semantic proximity Read

The biology of Lubricin: Near frictionless joint motionSemantic proximity Read

Friction-Induced Mitochondrial Dysregulation Contributes to Joint Deterioration in Prg4 Knockout MiceSemantic proximity Read

Homology of lubricin and superficial zone protein (SZP): Products of megakaryocyte stimulating factor (MSF) gene expression by human synovial fibroblasts and articular chondrocytes localized to chromosome 1q25Semantic proximity Read

Cathepsin B in osteoarthritis: uncontrolled proteolysis in the wrong place.Semantic proximity Read

Recombinant manufacturing of multispecies biolubricantsSemantic proximity Read

Cartilage Derived from Bone Marrow Mesenchymal Stem Cells Expresses Lubricin In Vitro and In VivoSemantic proximity Read