Article
Mutations of the anti-mullerian hormone gene in patients with persistent mullerian duct syndrome: biosynthesis, secretion, and processing of the abnormal proteins and analysis using a three-dimensional model.
Molecular endocrinology (Baltimore, Md.) - 1 Mar 2004
Belville Corinne, Van Vlijmen Herman, Ehrenfels Christian, Pepinsky Blake, Rezaie Alireza R, Picard Jean-Yves, Josso Nathalie, di Clemente Nathalie, Cate Richard L
Abstract excerpt
Anti-Müllerian hormone (AMH), a TGF-beta family member, determines whether an individual develops a uterus and Fallopian tubes. Mutations in the AMH gene lead to persistent Müllerian duct syndrome in males. The wild-type human AMH protein is synthesized as a disulfide-linked dimer of two identica...
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